New Study Shows Daily Supplementation with Pycnogenol® May Provide Relief from Recurrent Urinary Tract Infections

2022-06-10 22:20:18 By : Ms. Tina Yuan

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Researchers found that Pycnogenol® outperformed cranberry extract in reducing infection occurrence and decreasing painful symptoms, without side effects

HOBOKEN, N.J. , Aug. 4, 2021 /PRNewswire/ -- A new peer-reviewed and published study is revealing a natural option for the millions of women and men who suffer from recurrent urinary tract infections (UTIs). The open pilot registry study found the natural super-antioxidant Pycnogenol® French maritime pine bark extract to be effective at reducing the number of urinary tract infection episodes, increasing the number of infection-free and symptom-free patients, and decreasing oxidative stress in patients with urinary tract infections. In addition, researchers found daily supplementation with Pycnogenol® to reduce the number of episodes and decrease oxidative stress in patients with interstitial cystitis (IC).

Recurrent urinary tract infections are the result of a bacterial infection and defined as three episodes in the previous year or two episodes in the last six months. About 50 percent of women worldwide contract at least one urinary tract infection in their lifetime and 25–30 percent of women have at least one episode of recurrent urinary infections. Around 12 percent of men1 will experience urinary tract infections in their lifetime. Urinary tract infections cause up to 10 million visits2 to health care providers each year.

Similar to UTI, interstitial cystitis (IC) is a painful, often chronic disorder of the bladder, typically indicated by serious sensory lower urinary tract symptoms and pelvic pain but without bacterial occurrence in the urinalysis, estimated to impact between 3 and 6 percent of adult women.

"Patients who suffer from recurrent urinary tract infections often experience painful, disruptive symptoms including pain, burning and itching in the pelvic area, and a constant need to go to the bathroom. This study shows, Pycnogenol®, a natural ingredient, may reduce those symptoms," says Dr. Steven Lamm , MD, researcher, internist, and a leading expert on sexual health.

"It is important that we reduce the use of antibiotics in the management of recurrent urinary tract disorders. This study presents a potential natural alternative to antibiotic use. Pycnogenol® is known as an effective anti-inflammation agent. Important findings here that require further research," said Dr. Lamm.

Published in Evidence-Based Complementary and Alternative Medicine, the study encompassed 64 participants between the ages of 35 and 41. The test group was comprised of patients who reported at least three symptomatic urinary tract infections in the past year, reported at least two urinary tract infections in the past six months, or reported symptoms of urinary tract infections without bacterial occurrence in the urinalysis, such as interstitial cystitis.  

Three groups were tested in the study: a control group, a Pycnogenol® group, and a cranberry group. Each group was tested for 60 days and followed a standard management routine. The control group only followed the standard management routine, which consisted of accurate hygiene, improved bladder care, avoiding too much caffeine, spices, and alcohol, careful hydration, and mild exercise.

The Pycnogenol® group supplemented with 150mg of Pycnogenol® per day. The cranberry group supplemented with 400mg (two 200mg capsules) of dried cranberry extract (19 mg proanthocyanidins each) per day.

After 60 days of daily oral supplementation with 150mg of Pycnogenol®, results included:

The high impact of Pycnogenol® on the reduction of urinary tract infections/interstitial cystitis in patients compared to the effect of cranberry and standard management in this study corroborates with previous research demonstrating Pycnogenol®'s high antioxidative and anti-inflammatory effects.

To review clinical research and additional information on Pycnogenol®, visit Pycnogenol® is available in more than 1,000 dietary supplements and health products worldwide.

About Pycnogenol® Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 40 years and has more than 450 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than 1,000 dietary supplements and health products worldwide. For more information, visit  

About Horphag Research Horphag Research is the exclusive worldwide distributor for Pycnogenol® (pic-noj-en-all) brand French maritime pine bark extract. Pycnogenol® is a registered trademark of Horphag Research. For its patented ingredient, Pycnogenol®, Horphag Research has been awarded the Frost & Sullivan Excellence in Research Award, Nutraceutical Business & Technology Safety & Quality Award, SupplySide West Scientific Excellence Award and The American Botanical Council's Tyler Research Award. Horphag Research has the exclusive rights to market and sell Pycnogenol® worldwide and benefits from more than 40 years of scientific research assuring the safety and efficacy of Pycnogenol® as a dietary supplement.

1 Urology Care Foundation 2 Cleveland Clinic

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